Search Results - Therapeutic

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Repurpose PARP-1 Inhibitors for Type 2 Diabetes and Cystic Fibrosis Related Diabetes
Expand to Two Additional Indications for Existing DrugMarket NeedCurrent therapies for type 2 diabetes (T2D), including the closely similar cystic fibrosis related diabetes (CFRD), only address the symptoms, not the underlying pathophysiology of the disease. So instead of halting disease progression, the growing number of patients continue to have ...
Published: 5/10/2017   |   Inventor(s): Qianghua Xia, Struan Grant
Keywords(s): Cystic Fibrosis, Diabetes
Category(s): Therapeutic
Inhibit Immune Response In Implantable Medical Devices
Anti-Inflammatory Protein Immobilization to Combat In-Stent RestenosisMarket NeedOver 200 million people worldwide suffer from occlusive vascular disease (OVD), with prevalence rates increasing sharply given the aging global population. The definitive first line therapy for OVD is stent-angioplasty, however, restenosis, caused by the immune system&...
Published: 5/9/2017   |   Inventor(s): Stanley Stachelek, Dennis Discher, Robert Levy, Masako Ueda, Richard Tsai
Keywords(s): CD47
Category(s): Therapeutic
Protect Medical Device Implants Against Oxidative Damage
Oxidation Resistant Bioprosthetic TissuesMarket NeedOver 200,000 patients worldwide receive bioprosthetic heart valves. Compared to mechanical valves, bioprosthetics do not require patient anti-coagulation treatment. Although the risk of thromboembolism is significantly reduced, bioprosthetic valves demonstrate poor durability. Structural deteriora...
Published: 5/9/2017   |   Inventor(s): Robert Levy, Ivan Alferiev, Stanley Stachelek, Jeanne Connolly, Abigail Christian
Keywords(s): Anti-Oxidant
Category(s): Therapeutic
Harnessing viral strategies to suppress inflammation
Anti-inflammatory action through chromatin modulationMarket NeedInflammation is a hallmark of diseases such as sepsis, endotoxaemia, arthritis, acute respiratory disease, and multiple organ failure. Steroidal and non-steroidal anti-inflammatory medications (NSAIDS) both carry different risks, including risk of infection due to immune suppression wi...
Published: 2/23/2017   |   Inventor(s): Matthew Weitzman, G. Scott Worthen, Daphne C. Avgousti, Christin Herrmann, Andrew Paris
Keywords(s): Inflamation
Category(s): Therapeutic
Enhancing platelet production from megakaryocytes in-vitro
Sorting megakaryocytes by the presence of Factor V selects for cells with high platelet yieldMarket NeedPlatelets are critical as a first line treatment for trauma and hematological diseases. The demand for platelet transfusions is increasing along with the aging population and supply is often stressed in times of increased need. In fact, it has be...
Published: 2/23/2017   |   Inventor(s): Deborah French, Paul Gadue, Mortimer Poncz, Rodney Camire, Xiuli Sim
Keywords(s): Hematology
Category(s): Therapeutic
Treating B-cell Lymphoma by targeting a cell surface receptor
Inhibition of CD19 decreases oncogene expression and correlates with survival probability in patientsMarket NeedB-cell neoplasms, including lymphomas and acute lymphocytic leukemia (ALL), are cancers of the blood and bone marrow where cancerous expansion of white blood cells inhibits the production of other cell types and infiltrates into other org...
Published: 2/23/2017   |   Inventor(s): Andrei Thomas-Tikhonenko, Elaine Chung, James Psathas
Keywords(s): Oncology
Category(s): Therapeutic
Specific treatment of Graft Versus Host Disease (GVHD) without affecting graft efficacy
Inhibition of Crk proteins specifically targets GVHD while not affecting graft versus leukemiaMarket NeedGraft versus host disease (GVHD) can occur after an allogenic hematopoetic stem cell transplantation when the donor immune cells attack host tissue recognized as foreign. For oncology alone, allogenic stem cell therapeutics were an over five bil...
Published: 2/23/2017   |   Inventor(s): Janis Burkhardt, Yanping Huang, Taku Kambayashi
Keywords(s): Immunology
Category(s): Therapeutic
A Gene Therapy Approach to Treat Hepatitis C Virus (HCV) Infection
Delivery of a cluster of anti-HCV miRNA to neutralize HCV infection in liverMarket NeedIt is estimated that 3 percent of the world’s population is chronically infected with hepatitis C virus (HCV). Of those with HCV infections, 70 to 85 percent of individuals experience serious liver damage, including hepatocellular carcinoma. Current therapi...
Published: 1/25/2017   |   Inventor(s): Linda Couto
Keywords(s): HCV
Category(s): Therapeutic