Search Results - Therapeutic

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Decreasing Neutrophil Extracellular Traps (NETs) by administering a deglycosylated KKO antibody

Treating Sepsis with the Heparin-induced Thrombocytopenia-like Monoclonal Antibody KKO Decreasing Neutrophil Extracellular Traps (NETs) by administering a deglycosylated KKO antibodyMarket NeedSepsis is the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death. It is the 10th-leading...

Published: 6/28/2019 | Inventor(s): Mortimer Poncz, Kandace Gollomp, Lubica Rauova, Maria Anna Kowalska

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Category(s): Therapeutic

HS-binding peptides to selectively modulate BMP and other signaling pathways

Heparan Sulfate (HS) Binding Peptides as An Alternative to Bone Morphogenetic Protein (BMP) in Bone Disease TreatmentMarket NeedRecombinant bone morphogenetic protein (BMP) is used in orthopedic surgeries such as spinal fusion, long bone fracture sinus elevation, and localized alveolar/extraction socket defect repair. However, BMP is used in extremely...

Published: 7/1/2019 | Inventor(s): Paul Billings, Maurizio Pacifici

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Category(s): Therapeutic

Optimized discovery of tumor specific antigens for neuroblastoma immunotherapy

Data-driven discovery of tumor antigens using ligandomics, proteomics, and gene expressionMarket NeedThe current standard of care for high-risk neuroblastoma is extremely costly, involving an intense regimen of chemotherapy, radiation therapy, multiple surgeries, and immunotherapy (a typical treatment regimen for high-risk neuroblastoma can be found...

Published: 6/25/2019 | Inventor(s): John Maris, Mark Yarmarkovich

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Category(s): Therapeutic

FACTOR IX VARIANTS WITH ENHANCED BIOLOGICAL FUNCTIONS

Market NeedHemophilia B, also known as Christmas disease, is an x-linked genetic disorder caused by missing or defective Factor IX (FIX), a clotting protein. It is estimated that hemophilia occurs 1 in every 5000 births with 20,000 estimated to have hemophilia in the US alone. The severity of decrease in FIX levels in Hemophilia B patients varies from...

Published: 6/24/2019 | Inventor(s): Valder Arruda, Rodney Camire, Benjamin Samelson-Jones

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Category(s): Therapeutic

Chimeric Allo-Antigen Receptors (CALLARs) directed to Factor VIII autoantibodies

Market NeedHemophilia A is an inherited X-linked disease caused by Factor VIII (FVIII) deficiency and is a life-threatening bleeding disorder. The disease is associated with frequent hemarthosis and arthropathy that causes significant morbidity for patients. Factor replacement therapy using recombinant human FVIII (rhFVIII) is the standard of care for...

Published: 8/5/2019 | Inventor(s): Valder Arruda, Sarah Richman, Benjamin Samelson-Jones, Michael Milone

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Category(s): Therapeutic

Methods For The Generation Of Self Renewing Endodermal Precursor Populations Derived From Human Embryonic Stem Cells And Induced Pluripotent Stem Cells

Market NeedCell-based therapies for disease of endodermally derived organs such as the liver, pancreas, and intestines have gained significant interest. In addition to cell-based treatment strategies, there is a proven value in screening drugs in cellular models of the organ systems during development process. Commonly this screening is performed on...

Published: 6/6/2018 | Inventor(s): Paul Gadue, Deborah French, Xin Cheng

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Category(s): Therapeutic

GENE-EDITING OF FMR1 USING CRISPR/CAS9

Market NeedFragile X syndrome is an X-chromosome-linked disease that affects males more severely than females and is the most common cause of inherited intellectual disability, often co-occurring with Autism spectrum disorder. According to the CDC, around 1 in every 6000 males and 7000 females are born with the condition. Patients usually present with...

Published: 7/11/2019 | Inventor(s): Beverly Davidson, Carolyn Yrigollen, Alejandro Mas Monteys

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Category(s): Therapeutic

ALLELE SPECIFIC GENOME EDITING FOR HUNTINGTON'S DISEASE THERAPY

Market NeedHuntington’s Disease (HD) is an orphan neurodegenerative disease characterized by dementia, declining cognitive function, chorea that gradually spreads to all muscles, hypokinesia, rigidity, and other symptoms of psychomotor decline. Mean onset of symptoms is 30-50 years, however there is a juvenile onset form of HD that occurs under...

Published: 7/9/2019 | Inventor(s): Beverly Davidson, Alejandro Mas Monteys, Shauna Ebanks

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Category(s): Therapeutic

Repurpose PARP-1 Inhibitors for Type 2 Diabetes and Cystic Fibrosis Related Diabetes

Expand to Two Additional Indications for Existing DrugMarket NeedCurrent therapies for type 2 diabetes (T2D), including the closely similar cystic fibrosis related diabetes (CFRD), only address the symptoms, not the underlying pathophysiology of the disease. So instead of halting disease progression, the growing number of patients continue to have poor...

Published: 8/21/2019 | Inventor(s): Qianghua Xia, Struan Grant

Keywords(s): Cystic Fibrosis, Diabetes

Category(s): Therapeutic

Protect Medical Device Implants Against Oxidative Damage

Oxidation Resistant Bioprosthetic TissuesMarket NeedOver 200,000 patients worldwide receive bioprosthetic heart valves. Compared to mechanical valves, bioprosthetics do not require patient anti-coagulation treatment. Although the risk of thromboembolism is significantly reduced, bioprosthetic valves demonstrate poor durability. Structural deterioration...

Published: 6/24/2019 | Inventor(s): Robert Levy, Ivan Alferiev, Stanley Stachelek, Jeanne Connolly, Abigail Christian

Keywords(s): Anti-Oxidant

Category(s): Therapeutic

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