Latest technologies from The Children's Hospital of Philadelphia

ENDOTRACHEAL TUBE CURVE STABILIZER

Inventions@email.chop.edu — Mon, 12 Aug 2019 09:10:27 GMT

Disposable Anti-Kink Tracheal Tube Curve Stabilizer Each year, tens of millions of tracheal tubes (TT) are used in patients with impaired breathing or undergoing surgery to deliver oxygen and ventilation to the lungs. If a patient is being anesthetized, transported in an ambulance or helicopter, or having surgery on the head or neck, the TT that is inserted into the mouth is bent and taped or clipped to stabilize and maintain its proper position to prevent inadvertent displacement. This bending and securement often leads to TT kinking (as shown in the picture on the right), obstruction an...

Homology-independent intron targeting (HITI) for scalable tagging of endogenous genes

Inventions@email.chop.edu — Mon, 08 Jul 2019 12:12:03 GMT

Efficient and Scalable tagging of endogenous genes Homology-independent intron targeting (HITI) for scalable tagging of endogenous genes Market NeedFusing endogenous proteins with fluorescence or epitope tags is a widely used and essential approach for studying proteins within their natural regulatory context. The advent of CRISPR tools for modifying the genome has made this easier and even more accessible, yet scalability is still very limited. The need for a gene-specific Homology Directed Repair (HDR) template requires costly synthesis or labor-intensive molecular cloning, and since ...

Decreasing Neutrophil Extracellular Traps (NETs) by administering a deglycosylated KKO antibody

Inventions@email.chop.edu — Fri, 28 Jun 2019 07:30:41 GMT

Treating Sepsis with the Heparin-induced Thrombocytopenia-like Monoclonal Antibody KKO Decreasing Neutrophil Extracellular Traps (NETs) by administering a deglycosylated KKO antibody Market NeedSepsis is the body’s overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death. It is the 10th-leading cause of death in the United States. Annual economic burden is estimated at $16.7 billion. However, sepsis is treatable if it is identified and treated quickly. Technology OverviewThe Poncz lab demonstrated that a...

HS-binding peptides to selectively modulate BMP and other signaling pathways

Inventions@email.chop.edu — Thu, 13 Jun 2019 05:39:45 GMT

Heparan Sulfate (HS) Binding Peptides as An Alternative to Bone Morphogenetic Protein (BMP) in Bone Disease Treatment Market NeedRecombinant bone morphogenetic protein (BMP) is used in orthopedic surgeries such as spinal fusion, long bone fracture sinus elevation, and localized alveolar/extraction socket defect repair. However, BMP is used in extremely high doses and has a short half-life. Adverse effects have been documented such as local edema, erythema, pain, surgical site infection, graft failure, and pseudoarthrosis. Problems are more common after off-label uses including graft failu...

Improved Blood Transfusion Screening with iPSC-derived Reagents

Inventions@email.chop.edu — Mon, 09 Jul 2018 11:29:51 GMT

Red Blood Cell (RBC) Reagents with Rare Antigen Phenotypes for Prevention of Alloimmunization Reaction in SCD Patients Market NeedSickle cell disease is an autosomal recessive blood disorder genes that leads to the affected patient’s hemoglobin is abnormal, causing RBCs to become hard, sickle-shaped, and less efficient at carrying oxygen. There are over 4.4 million patients worldwide living with SCD, which is more prevalent in certain populations, such as in Sub Saharan Africa, Saudi Arabia, India, Mediterranean countries, and African Americans in the United States. Disease manageme...

Optimized discovery of tumor specific antigens for neuroblastoma immunotherapy

Inventions@email.chop.edu — Mon, 09 Jul 2018 11:06:58 GMT

Data-driven discovery of tumor antigens using ligandomics, proteomics, and gene expression Market NeedThe current standard of care for high-risk neuroblastoma is extremely costly, involving an intense regimen of chemotherapy, radiation therapy, multiple surgeries, and immunotherapy (a typical treatment regimen for high-risk neuroblastoma can be found at http://neuroblastoma.ca/845/). Most high-risk patients suffer a relapse during or after these therapies, and survivors are left with extreme morbidities including stunted growth, cognitive impairment, sterility, and increased incidence of ...

Quantitative phenotyping to automate diagnosis of autism spectrum disorder (ASD)

Inventions@email.chop.edu — Mon, 09 Jul 2018 10:58:58 GMT

Using machine learning to identify features of ASD Market NeedAutism spectrum disorder is a developmental disorder that affects communication and behavior. Usually, the disorder is first detected through observation within the first 36 months of age looking for specific developmental milestones. Usually, it is the parents who first raise concerns of their child’s unusual behavior, such as not responding to their name or not making eye contact, which leads to further evaluation. After the doctor refers the child to a developmental specialist further evaluations are done by a multi-di...

Malabsorption Blood Test Extension Beyond Pancreatic Based Diagnosis

Inventions@email.chop.edu — Wed, 16 May 2018 11:32:06 GMT

Fat Malabsorption Diagnostic Drink and Blood TestLess than 72 hours, No Stool Sample Required TECHNOLOGY OVERVIEWFat malabsorption results from various diseases such as pancreatitis, pancreatic cancer and cystic fibrosis. If left undiagnosed, fat malabsorption leads to severe malnutrition, nutritional deficiencies, unwanted weight loss and chronic diarrhea. But, the current gold standard diagnostic test for fat malabsorption called gravimetric test makes immediate diagnosis challenging. The acid steatocrit test requires stool sample collection over 3 days and to weigh and record food cons...

PHRASE (Public Health Rules Assessment Support Engine)

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:46:49 GMT

PHRASE is a clinical decision support management platform that willhelp you understand the usage of clinical decision support assets inyour electronic health record. PHRASE provides tools for ongoingmaintenance and continual improvement of decision support. Key Features• Organize alerts in the electronic health record assearchable data• Provide insight into how often alerts are seenand how providers are responding them• Enable tracking of alert ownership andcontextual information about alert contents PHRASE Health was created atChildren’s Hospital of Philadelphia...

FACTOR IX VARIANTS WITH ENHANCED BIOLOGICAL FUNCTIONS

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:44:57 GMT

Market NeedHemophilia B, also known as Christmas disease, is an x-linked genetic disorder caused by missing or defective Factor IX (FIX), a clotting protein. It is estimated that hemophilia occurs 1 in every 5000 births with 20,000 estimated to have hemophilia in the US alone. The severity of decrease in FIX levels in Hemophilia B patients varies from mild to severe and in severe cases, which represent approximately 60% of cases, the decreased levels of FIX (<1% of FIX in blood) causes patients to experience frequent spontaneous bleeding episodes and bleeding episodes after injuries. Curren...

Chimeric Allo-Antigen Receptors (CALLARs) directed to Factor VIII autoantibodies

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:44:10 GMT

Market NeedHemophilia A is an inherited X-linked disease caused by Factor VIII (FVIII) deficiency and is a life-threatening bleeding disorder. The disease is associated with frequent hemarthosis and arthropathy that causes significant morbidity for patients. Factor replacement therapy using recombinant human FVIII (rhFVIII) is the standard of care for patients with hemophilia A. Unfortunately, 10-40% of patients with hemophilia develop antibodies (alloantibodies) to plasma-derived or recombinant human FVIII protein that inhibits the recombinant FVIII function. The consequences of allow antibod...

Methods For The Generation Of Self Renewing Endodermal Precursor Populations Derived From Human Embryonic Stem Cells And Induced Pluripotent Stem Cells

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:42:39 GMT

Market NeedCell-based therapies for disease of endodermally derived organs such as the liver, pancreas, and intestines have gained significant interest. In addition to cell-based treatment strategies, there is a proven value in screening drugs in cellular models of the organ systems during development process. Commonly this screening is performed on induced pluripotent stem cells that require a complex and lengthy process to create a differentiated cell type from these cells for each screen. There is a need for a simpler method to create endodermal progenitor cells for both treatment and scree...

Discovery Of Novel CVID Loci Using The Exome SNP Chip Platform

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:41:29 GMT

Center for Applied Genomics (CAG) at CHOPThe Center for Applied Genomics is one of the world's largest genetics research programs, and the only center at a pediatric hospital to have large-scale access to high-throughput genotyping technology. There are over 50 active disease projects – both internally and in collaboration with researchers across North America, Europe, and Asia. This unique resource enables large-scale human genotyping studies: to date, genetic data from over 100,000 individuals has been analyzed. The Center for Applied Genomics is focused on detecting the genetic causes...

Genome- And Phenome-Wide Association Analyses Uncovers MET as a Susceptibility Gene of Cerebral Palsy

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:40:47 GMT

GENE-EDITING OF FMR1 USING CRISPR/CAS9

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:39:03 GMT

Market NeedFragile X syndrome is an X-chromosome-linked disease that affects males more severely than females and is the most common cause of inherited intellectual disability, often co-occurring with Autism spectrum disorder. According to the CDC, around 1 in every 6000 males and 7000 females are born with the condition. Patients usually present with delay in reaching early language and communication milestones, lower than average intelligence quotient that declines with age, attention problems, anxiety, self-injury, hypersensitivity, and aggressiveness. Genetically, the disease is caused by ...

ALLELE SPECIFIC GENOME EDITING FOR HUNTINGTON'S DISEASE THERAPY

Inventions@email.chop.edu — Tue, 27 Feb 2018 13:37:59 GMT

Market NeedHuntington’s Disease (HD) is an orphan neurodegenerative disease characterized by dementia, declining cognitive function, chorea that gradually spreads to all muscles, hypokinesia, rigidity, and other symptoms of psychomotor decline. Mean onset of symptoms is 30-50 years, however there is a juvenile onset form of HD that occurs under age 20. The progressive neurodegeneration leads to death on average of 20 years after the age of onset. Both forms of the disease are caused by mutations in the huntington (HTT) gene that causes excessive cytosine, adenine, and guanine (CAG) repea...

Repurpose PARP-1 Inhibitors for Type 2 Diabetes and Cystic Fibrosis Related Diabetes

Inventions@email.chop.edu — Wed, 10 May 2017 09:02:07 GMT

Expand to Two Additional Indications for Existing Drug Market Need Current therapies for type 2 diabetes (T2D), including the closely similar cystic fibrosis related diabetes (CFRD), only address the symptoms, not the underlying pathophysiology of the disease. So instead of halting disease progression, the growing number of patients continue to have poor glycemic control and suffer side effects from these symptomatic drugs. Technology Overview Dr. Struan Grant discovered the strongest genetic factor for T2D reported to date – harbored within the TCF7L2 gene (Nature Ge...

Efficiently and Clearly Record Genetic Information during Genetic Counseling Sessions

Inventions@email.chop.edu — Wed, 10 May 2017 08:31:24 GMT

Proband: A User-friendly, Concise Pedigree Chart Software Market Need Genetic counselors need to quickly and accurately record the familial relationships and their corresponding health conditions of a patient as the patient is recalling the information during an in-person genetic counsel session. Further, these records should be easy to understand for patients and other clinicians long after the session. Technology Overview Proband is a family history pedigree chart software used by genetic counselors to increase patient understanding and efficiency during counseling sessio...

Detect Mulitple Types of Epithelial Tumors and Determine Cancer Sage with ONe Biomarker

Inventions@email.chop.edu — Tue, 09 May 2017 12:15:35 GMT

ZEB1 expression levels predict metastatic potential Market Need Clinicians and pathologists need to determine the stage of cancer progression in a patient to determine the appropriate course of treatment. Currently, there are two methods to determine the stage of a patient’s cancer. The first involves taking a biopsy of the suspected tissue mass, which is stained. Based on the staining results, a pathologist estimates the stage of cancer. The second method is a blood test that measures levels of biomarkers for specific types of cancer. The first method relies on the expertise ...

Diagnostic Test for Cornelia de Lange Syndrome (CdLS)

Inventions@email.chop.edu — Tue, 09 May 2017 12:07:21 GMT

Identify Patients and Carriers of CdLS Market Need The Cornelia de Lange syndrome (CdLS) is a dominantly inherited multisystem developmental disorder that includes growth and cognitive retardation, upper extremity abnormalities, gastroesophageal dysfunction, cardiac ophthalmologic genitourinary anomalies, hirsutism and characteristic facial features. Many patients also demonstrate autistic behavior, including self-injurious tendencies. Prevalence is estimated to be as high as 1 in 10,000. Diagnosis and counseling for CdLS has been complicated by phenotypic variability and lack of a ...

Metal Surface Compatible Gene Therapy

Inventions@email.chop.edu — Tue, 09 May 2017 12:00:10 GMT

Site-specific delivery for in-stent restenonsis Market Need Cardiovascular diseases (CVD) are the leading cause of death in Europe, the United States and Japan and are expected to grow globally as the population ages. An effective treatment for coronary blockages resulting from CVD is stent implantation. The treatment though is short lived as restenosis, an immune response, develops around the stent. Polymer-coated gene-delivery stents have been shown to further prolong restenosis. Metal surface stents have a less pronounced inflammatory response than the polymer coated version but a...

Protect Medical Device Implants Against Oxidative Damage

Inventions@email.chop.edu — Tue, 09 May 2017 11:28:50 GMT

Oxidation Resistant Bioprosthetic Tissues Market Need Over 200,000 patients worldwide receive bioprosthetic heart valves. Compared to mechanical valves, bioprosthetics do not require patient anti-coagulation treatment. Although the risk of thromboembolism is significantly reduced, bioprosthetic valves demonstrate poor durability. Structural deterioration results in reoperations in more than a quarter of patients. Aside from failure due to accumulation of calcium deposits on the valve surface, other factors impacting durability remain poorly understood. Technology Overview D...

Continuous, Convenient Lymphatic Drainage System

Inventions@email.chop.edu — Tue, 09 May 2017 10:56:53 GMT

Medical Device Implant to Prevent Lymphatic Congestions Market Need Patients with congestive heart failure (CHF) develop poor lymphatic production and drainage. As a result, patients develop tissue edema and liver enlargement. In patients with CHF, poor lymphatic drainage is due to a decrease lymphatic outflow due to central venous pressure elevation. Currently, there are two treatments for poor lymphatic drainage. One is external decompression, which has shown improvements but require clinical visits. The other form of treatment is external drainage of lymphatic fluid from the thora...

Detection of HER2 in Urine to Diagnose Lupus Nephritis (LN)

Inventions@email.chop.edu — Thu, 23 Feb 2017 04:25:34 GMT

Point-of-care biomarker for Systemic Lupus Nephritis Market Need Systemic Lupus Erythematosus (SLE) is an autoimmune disease that varies in severity in which the patient’s immune system mistakenly attacks healthy tissues in the body. Lupus Nephritis (LN) is kidney inflammation, which is a complication of SLE that causes decreased kidney function. LN is often difficult to diagnose because the symptoms, which include painful swollen joints, fever, feeling tired, and swollen lymph nodes, can vary and be misdiagnosed for other diseases. Currently, diagnosing LN requires a non-defin...

Platform technology for direct targeting of therapeutics to neurons

Inventions@email.chop.edu — Thu, 23 Feb 2017 04:21:25 GMT

Fusion with a humanized tetanus-toxin C fragment (TTC) targets proteins to neurons Market Need Neurological diseases including Alzheimer’s, Parkinson’s and epilepsy, are one of the largest and fastest growing markets with a projected worth of over 1.5 billion dollars in 2012 and large projected growth coinciding with an aging population. On average, CNS drug development takes at least twice as long as drugs in areas such as cardiovascular in part because of the difficulty that injectable or oral drugs have in penetrating the blood-brain barrier. Thus, there is a nee...

Harnessing viral strategies to suppress inflammation

Inventions@email.chop.edu — Thu, 23 Feb 2017 04:12:39 GMT

Anti-inflammatory action through chromatin modulation Market Need Inflammation is a hallmark of diseases such as sepsis, endotoxaemia, arthritis, acute respiratory disease, and multiple organ failure. Steroidal and non-steroidal anti-inflammatory medications (NSAIDS) both carry different risks, including risk of infection due to immune suppression with steroid use and increased risk of heart attack or stroke that has recently been highlighted by the FDA in regards to NSAIDs. Other anti-inflammatory drugs, such as anti-TNF-alpha antibodies, can be costly and not appropriate for all in...

Treating B-cell Lymphoma by targeting a cell surface receptor

Inventions@email.chop.edu — Thu, 23 Feb 2017 04:01:15 GMT

Inhibition of CD19 decreases oncogene expression and correlates with survival probability in patients Market Need B-cell neoplasms, including lymphomas and acute lymphocytic leukemia (ALL), are cancers of the blood and bone marrow where cancerous expansion of white blood cells inhibits the production of other cell types and infiltrates into other organs. It is reported that the global treatment market for non-Hodgkin lymphoma will increase to over nine billion dollars by 2020 with a compound annual growth rate of 7.4%. Currently, the CD20 targeting antibody Rituxumab has been effecti...

Specific treatment of Graft Versus Host Disease (GVHD) without affecting graft efficacy

Inventions@email.chop.edu — Thu, 23 Feb 2017 03:43:24 GMT

Inhibition of Crk proteins specifically targets GVHD while not affecting graft versus leukemia Market Need Graft versus host disease (GVHD) can occur after an allogenic hematopoetic stem cell transplantation when the donor immune cells attack host tissue recognized as foreign. For oncology alone, allogenic stem cell therapeutics were an over five billion dollar market in the US and Europe combined. Of the estimated 50,000 hematopoetic stem cell transplants occurring annually, up to 70% of patients develop some degree of GVHD. The disease can manifest as rashes or dermatitis, hepatiti...

Automated detection of proper endotracheal intubation

Inventions@email.chop.edu — Wed, 22 Feb 2017 06:06:23 GMT

Software to detect proper endotracheal tube (ETT) placement using existing ventilator parameters Market Need Hundreds of operations necessitate endotracheal intubation each year in the US, of which there are often complications that arise from improper placement of the endotracheal tube. In a pediatric setting, where this is even more difficult due to small airway size, one study reported that the higher the number of attempts of tracheal intubation was related to increase in trauma, hypoxia, and bradycardia and an accidental extubation rate of 20%. Another multicenter study reported...

Non-invasive biomarker specific for Crohn's disease diagnosis

Inventions@email.chop.edu — Fri, 03 Feb 2017 03:18:41 GMT

Serum miRNA panel for non-invasive diagnosis and monitoring of Crohn’s disease Market Need Approximately 1.6 billion people in the US alone have inflammatory bowel disease, which includes Crohn’s disease. These chronic diseases, which have a significant impact on quality of life, can be treated but not cured. According to estimates based on insurance claims data, the direct annual cost of Crohn’s disease ranges from 8 -18 thousand dollars per patient, including the cost of lengthy diagnostic procedures for the disease. Because inflammation in Crohn’s can affec...

A Gene Therapy Approach to Treat Hepatitis C Virus (HCV) Infection

Inventions@email.chop.edu — Wed, 25 Jan 2017 04:41:43 GMT

Delivery of a cluster of anti-HCV miRNA to neutralize HCV infection in liver Market Need It is estimated that 3 percent of the world’s population is chronically infected with hepatitis C virus (HCV). Of those with HCV infections, 70 to 85 percent of individuals experience serious liver damage, including hepatocellular carcinoma. Current therapies, including a yearlong treatment with a combination of pegylated interferon-α and ribavirin, are only partially effective because of the genetic diversity of HCV genotypes and the high mutation rate of the virus. In addition, the ...