Latest technologies from The Children's Hospital of Philadelphiahttp://technologytransfer.research.chop.eduBe the first to know about the latest inventions and technologies available from The Children's Hospital of Philadelphiaen-USSun, 18 Mar 2018 00:47:29 GMTTue, 27 Feb 2018 13:46:49 GMT 2018, The Children's Hospital of PhiladelphiaPHRASE (Public Health Rules Assessment Support Engine), 27 Feb 2018 13:46:49 GMTInventions@email.chop.edu IX Variants With Enhanced Biological Functions, 27 Feb 2018 13:44:57 GMTInventions@email.chop.edu Allo-Antigen Receptors (CALLARs) directed to Factor VIII autoantibodies NeedHemophilia A is an inherited X-linked disease caused by Factor VIII (FVIII) deficiency and is a life-threatening bleeding disorder. The disease is associated with frequent hemarthosis and arthropathy that causes significant morbidity for patients. Factor replacement therapy using recombinant human FVIII (rhFVIII) is the standard of care for patients with hemophilia A. Unfortunately, 10-40% of patients with hemophilia develop antibodies (alloantibodies) to plasma-derived or recombinant human FVIII protein that inhibits the recombinant FVIII function. The consequences of allow antibod...Tue, 27 Feb 2018 13:44:10 GMTInventions@email.chop.edu For The Generation Of Self Renewing Endodermal Precursor Populations Derived From Human Embryonic Stem Cells And Induced Pluripotent Stem Cells NeedCell-based therapies for disease of endodermally derived organs such as the liver, pancreas, and intestines have gained significant interest. In addition to cell-based treatment strategies, there is a proven value in screening drugs in cellular models of the organ systems during development process. Commonly this screening is performed on induced pluripotent stem cells that require a complex and lengthy process to create a differentiated cell type from these cells for each screen. There is a need for a simpler method to create endodermal progenitor cells for both treatment and scree...Tue, 27 Feb 2018 13:42:39 GMTInventions@email.chop.edu Of Novel CVID Loci Using The Exome SNP Chip Platform, 27 Feb 2018 13:41:29 GMTInventions@email.chop.edu And Phenome-Wide Association Analyses Uncovers MET as a Susceptibility Gene of Cerebral Palsy, 27 Feb 2018 13:40:47 GMTInventions@email.chop.edu GRN Gene Delivery For Therapy Of Frontotemporal Dementia Due To Progranulin Mutations, 27 Feb 2018 13:39:57 GMTInventions@email.chop.edu Of FMR1 Using CRISPR/Cas9 NeedFragile X syndrome is an X-chromosome-linked disease that affects males more severely than females and is the most common cause of inherited intellectual disability, often co-occurring with Autism spectrum disorder. According to the CDC, around 1 in every 6000 males and 7000 females are born with the condition. Patients usually present with delay in reaching early language and communication milestones, lower than average intelligence quotient that declines with age, attention problems, anxiety, self-injury, hypersensitivity, and aggressiveness. Genetically, the disease is caused by ...Tue, 27 Feb 2018 13:39:03 GMTInventions@email.chop.edu Specific Genome Editing For Huntington's Disease Therapy, 27 Feb 2018 13:37:59 GMTInventions@email.chop.edu PARP-1 Inhibitors for Type 2 Diabetes and Cystic Fibrosis Related Diabetes, 10 May 2017 09:02:07 GMTInventions@email.chop.edu and Clearly Record Genetic Information during Genetic Counseling Sessions, 10 May 2017 08:31:24 GMTInventions@email.chop.edu Mulitple Types of Epithelial Tumors and Determine Cancer Sage with ONe Biomarker, 09 May 2017 12:15:35 GMTInventions@email.chop.edu Test for Cornelia de Lange Syndrome (CdLS), 09 May 2017 12:07:21 GMTInventions@email.chop.edu Surface Compatible Gene Therapy, 09 May 2017 12:00:10 GMTInventions@email.chop.edu Medical Device Implants Against Oxidative Damage, 09 May 2017 11:28:50 GMTInventions@email.chop.edu, Convenient Lymphatic Drainage System, 09 May 2017 10:56:53 GMTInventions@email.chop.edu Test for Alagille Syndrome, 09 May 2017 10:22:10 GMTInventions@email.chop.edu Simple Blood Test for Pancreatic Function, 09 May 2017 10:14:03 GMTInventions@email.chop.edu of HER2 in Urine to Diagnose Lupus Nephritis (LN), 23 Feb 2017 04:25:34 GMTInventions@email.chop.edu technology for direct targeting of therapeutics to neurons, 23 Feb 2017 04:21:25 GMTInventions@email.chop.edu viral strategies to suppress inflammation, 23 Feb 2017 04:12:39 GMTInventions@email.chop.edu platelet production from megakaryocytes in-vitro, 23 Feb 2017 04:05:03 GMTInventions@email.chop.edu B-cell Lymphoma by targeting a cell surface receptor, 23 Feb 2017 04:01:15 GMTInventions@email.chop.edu treatment of Graft Versus Host Disease (GVHD) without affecting graft efficacy, 23 Feb 2017 03:43:24 GMTInventions@email.chop.edu detection of proper endotracheal intubation, 22 Feb 2017 06:06:23 GMTInventions@email.chop.edu biomarker specific for Crohn's disease diagnosis, 03 Feb 2017 03:18:41 GMTInventions@email.chop.edu Gene Therapy Approach to Treat Hepatitis C Virus (HCV) Infection, 25 Jan 2017 04:41:43 GMTInventions@email.chop.edu