Search Results - valder arruda

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Factor IX Variants With Enhanced Biological Functions
Market NeedHemophilia B, also known as Christmas disease, is an x-linked genetic disorder caused by missing or defective Factor IX (FIX), a clotting protein. It is estimated that hemophilia occurs 1 in every 5000 births with 20,000 estimated to have hemophilia in the US alone. The severity of decrease in FIX levels in Hemophilia B patients varies f...
Published: 2/27/2018   |   Inventor(s): Valder Arruda, Rodney Camire, Benjamin Samelson-Jones
Keywords(s):  
Category(s): Therapeutic
Chimeric Allo-Antigen Receptors (CALLARs) directed to Factor VIII autoantibodies
Market NeedHemophilia A is an inherited X-linked disease caused by Factor VIII (FVIII) deficiency and is a life-threatening bleeding disorder. The disease is associated with frequent hemarthosis and arthropathy that causes significant morbidity for patients. Factor replacement therapy using recombinant human FVIII (rhFVIII) is the standard of care ...
Published: 2/27/2018   |   Inventor(s): Valder Arruda, Sarah Richman, Benjamin Samelson-Jones, Michael Milone
Keywords(s):  
Category(s): Therapeutic